Network Pharmacology-Based Study on the Mechanism of Aloe Vera for Treating Cancer.

ABSTRACT:

Background

Aloe vera has long been considered an anticancer herb in different parts of the world.

Objective

To explore the potential mechanism of aloe vera in the treatment of cancer using network pharmacology and molecule docking approaches.

Methods

The active ingredients and corresponding protein targets of aloe vera were identified from the TCMSP database. Targets related to cancer were obtained from GeneCards and OMIM databases. The anticancer targets of aloe vera were obtained by intersecting the drug targets with the disease targets, and the process was presented in the form of a Venn plot. These targets were uploaded to the String database for protein-protein interaction (PPI) analysis, and the result was visualized by Cytoscape software. Go and KEGG enrichment

SUBMITTER: Xie J 

PROVIDER: S-EPMC8654547 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature