⁶⁸Ga-P15-041, A Novel Bone Imaging Agent for Diagnosis of Bone Metastases.

ABSTRACT:

Objectives

⁶⁸Ga-P15-041 (⁶⁸Ga-HBED-CC-BP) is a novel bone-seeking PET radiotracer, which can be readily prepared by using a simple kit formulation and an in-house ⁶⁸Ga/⁶⁸Ge generator. The aim of this study is to assess the potential human application of ⁶⁸Ga-P15-041 for clinical PET/CT imaging and to compare its efficacy to detect bone metastases of different cancers with ⁹⁹mTc-MDP whole-body bone scintigraphy (WBBS).

Methods

Initial kinetic study using Patlak analysis and parametric maps were performed in five histopathologically proven cancer patients (three males, two females) using ⁶⁸Ga-P15-041 PET/CT scan only. Another group of 51 histopathologically proven cancer patients (22 males, 29 females

SUBMITTER: Guo R 

PROVIDER: S-EPMC8654731 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature