Ferroptosis-related gene signature correlates with the tumor immune features and predicts the prognosis of glioma patients.

ABSTRACT: Glioma is a malignant intracranial tumor and the most fatal cancer. The role of ferroptosis in the clinical progression of gliomas is unclear. Univariate and least absolute shrinkage and selection operator (Lasso) Cox regression methods were used to develop a ferroptosis-related signature (FRSig) using a cohort of glioma patients from the Chinese Glioma Genome Atlas (CGGA), and was validated using an independent cohort of glioma patients from The Cancer Genome Atlas (TCGA). A single-sample gene set enrichment analysis (ssGSEA) was used to calculate levels of the immune infiltration. Multivariate Cox regression was used to determine the independent prognostic role of clinicopathological factors and to establish a nomogram model for clinical application. We analyzed the correlations between

SUBMITTER: Hu Y 

PROVIDER: S-EPMC8655507 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature