POLR2A Promotes the Proliferation of Gastric Cancer Cells by Advancing the Overall Cell Cycle Progression.
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ABSTRACT:
SUBMITTER: Jiang Q
PROVIDER: S-EPMC8655910 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
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POLR2A Promotes the Proliferation of Gastric Cancer Cells by Advancing the Overall Cell Cycle Progression.
Jiang Qiuyu Q Zhang Jinyuan J Li Fang F Ma Xiaoping X Wu Fei F Miao Jiyu J Li Qian Q Wang Xiaofei X Sun Ruifang R Yang Yang Y Zhao Lingyu L Huang Chen C
Frontiers in genetics 20211125
RNA polymerase II subunit A (POLR2A) is the largest subunit encoding RNA polymerase II and closely related to cancer progression. However, the biological role and underlying molecular mechanism of POLR2A in gastric cancer (GC) are still unclear. Our study demonstrated that POLR2A was highly expressed in GC tissue and promoted the proliferation of GC <i>in vitro</i> and <i>in vivo</i>. We also found that POLR2A participated in the transcriptional regulation of cyclins and cyclin-dependent kinases ...[more]
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