Unknown

Dataset Information

0

Analysis of somatic copy number alterations in biliary tract carcinoma using a single nucleotide polymorphism array.


ABSTRACT: Aim:Biliary tract carcinoma (BTC), including gall bladder carcinoma (GBC) and biliary duct carcinoma (BDC), has a poor prognosis. Comprehensive genomic profiling has important roles in evaluation of the carcinogenesis of BTC. Materials & methods:We examined somatic copy number alterations (SCNAs) using a single nucleotide polymorphism array system to analyze 36 BTC samples (11 GBCs and 25 BDCs). Results:In hierarchical cluster analysis, two clusters were identified (subgroup 1 with low SCNAs and subgroup 2 with high SCNAs). GBC was predominant in subgroup 1, whereas BDC was predominant in subgroup 2, suggesting that GBC and BDC had different genetic backgrounds in terms of SCNAs. Conclusion:These findings could be helpful for establishing the molecular carcinogenesis of BTCs.

SUBMITTER: Shioi Y 

PROVIDER: S-EPMC8656348 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC3581983 | biostudies-literature
| S-EPMC7079091 | biostudies-literature
| S-EPMC7080958 | biostudies-literature
| S-EPMC7956176 | biostudies-literature
| S-EPMC10646480 | biostudies-literature
| S-EPMC9881990 | biostudies-literature
| S-EPMC5528970 | biostudies-other
| S-EPMC4637328 | biostudies-literature
| S-EPMC5398631 | biostudies-literature
| S-EPMC7331695 | biostudies-literature