Ontology highlight
ABSTRACT:
SUBMITTER: Martinez-Perez D
PROVIDER: S-EPMC8656894 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Martinez-Perez Daniel D Viñal David D Solares Isabel I Espinosa Enrique E Feliu Jaime J
Cancers 20211127 23
Uveal melanoma is a rare neoplasm with poor prognosis in the metastatic setting. Unlike cutaneous melanoma, treatment with kinase inhibitors or immune checkpoint inhibitors is not effective. Glycoprotein 100 (Gp-100) is a protein highly expressed in melanocytes and melanoma that has recently been effectively targeted by tebentafusp, a first-in-class bispecific protein of the immune-mobilizing monoclonal T cell receptors against cancer (ImmTACs) family. Tebentafusp targets tumor cells that expres ...[more]