Ontology highlight
ABSTRACT:
SUBMITTER: Hertz E
PROVIDER: S-EPMC8657933 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Hertz Ellen E Saarinen Marcus M Svenningsson Per P
International journal of molecular sciences 20211127 23
G-protein-coupled receptors (GPCRs) are commonly pharmacologically modulated due to their ability to translate extracellular events to intracellular changes. Previously, studies have mostly focused on protein-protein interactions, but the focus has now expanded also to protein-lipid connections. GM1, a brain-expressed ganglioside known for neuroprotective effects, and GPR37, an orphan GPCR often reported as a potential drug target for diseases in the central nervous system, have been shown to fo ...[more]