Ontology highlight
ABSTRACT:
SUBMITTER: Roayapalley PK
PROVIDER: S-EPMC8659243 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20211125 23
A novel series of 1-[3-{3,5-bis(benzylidene)-4-oxo-1-piperidino}-3-oxopropyl]-4-piperidone oximes <b>3a</b>-<b>h</b> and related quaternary ammonium salts <b>4a</b>-<b>h</b> were prepared as candidate antineoplastic agents. Evaluation against neoplastic Ca9-22, HSC-2 and HSC-4 cells revealed the compounds in series <b>3</b> and <b>4</b> to be potent cytotoxins with submicromolar CC<sub>50</sub> values in virtually all cases. In contrast, the compounds were less cytocidal towards HGF, HPLF and HP ...[more]