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Continuous Flow Synthesis of Propofol.

ABSTRACT: Herein, we report a continuous flow process for the synthesis of 2,6-diisopropylphenol-also known as Propofol-a short-acting intravenous anesthesia, widely used in intensive care medicine to provide sedation and hypnosis. The synthesis is based on a two-step procedure: a double Friedel-Crafts alkylation followed by a decarboxylation step, both under continuous flow.

SUBMITTER: Mougeot R

PROVIDER: S-EPMC8659244 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

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Continuous Flow Synthesis of Propofol.

Mougeot Romain R Jubault Philippe P Legros Julien J Poisson Thomas T

Molecules (Basel, Switzerland) 20211126 23

Herein, we report a continuous flow process for the synthesis of 2,6-diisopropylphenol-also known as Propofol-a short-acting intravenous anesthesia, widely used in intensive care medicine to provide sedation and hypnosis. The synthesis is based on a two-step procedure: a double Friedel-Crafts alkylation followed by a decarboxylation step, both under continuous flow. ...[more]

PMID: 34885756

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