Generative Adversarial Networks to Improve Fetal Brain Fine-Grained Plane Classification.
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ABSTRACT:
SUBMITTER: Montero A
PROVIDER: S-EPMC8659720 | biostudies-literature |
REPOSITORIES: biostudies-literature
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Project description:PurposeTo assess the contribution of a generative adversarial network (GAN) to improve intermanufacturer reproducibility of radiomic features (RFs).Materials and methodsThe authors retrospectively developed a cycle-GAN to translate texture information from chest radiographs acquired using one manufacturer (Siemens) to chest radiographs acquired using another (Philips), producing fake chest radiographs with different textures. The authors prospectively evaluated the ability of this texture-translation cycle-GAN to reduce the intermanufacturer variability of RFs extracted from the lung parenchyma. This study assessed the cycle-GAN's ability to fool several machine learning (ML) classifiers tasked with recognizing the manufacturer on the basis of chest radiography inputs. The authors also evaluated the cycle-GAN's ability to mislead radiologists who were asked to perform the same recognition task. Finally, the authors tested whether the cycle-GAN had an impact on radiomic diagnostic accuracy for chest radiography in patients with congestive heart failure (CHF).ResultsRFs, extracted from chest radiographs after the cycle-GAN's texture translation (fake chest radiographs), showed decreased intermanufacturer RF variability. Using cycle-GAN-generated chest radiographs as inputs, ML classifiers categorized the fake chest radiographs as belonging to the target manufacturer rather than to a native one. Moreover, cycle-GAN fooled two experienced radiologists who identified fake chest radiographs as belonging to a target manufacturer class. Finally, reducing intermanufacturer RF variability with cycle-GAN improved the discriminative power of RFs for patients without CHF versus patients with CHF (from 55% to 73.5%, P < .001).ConclusionBoth ML classifiers and radiologists had difficulty recognizing the chest radiographs' manufacturer. The cycle-GAN improved RF intermanufacturer reproducibility and discriminative power for identifying patients with CHF. This deep learning approach may help counteract the sensitivity of RFs to differences in acquisition.Supplemental material is available for this article.© RSNA, 2020See also the commentary by Alderson in this issue.
| S-EPMC8082326 | biostudies-literature
Project description:The performance of artificial intelligence (AI) for brain MRI can improve if enough data are made available. Generative adversarial networks (GANs) showed a lot of potential to generate synthetic MRI data that can capture the distribution of real MRI. Besides, GANs are also popular for segmentation, noise removal, and super-resolution of brain MRI images. This scoping review aims to explore how GANs methods are being used on brain MRI data, as reported in the literature. The review describes the different applications of GANs for brain MRI, presents the most commonly used GANs architectures, and summarizes the publicly available brain MRI datasets for advancing the research and development of GANs-based approaches. This review followed the guidelines of PRISMA-ScR to perform the study search and selection. The search was conducted on five popular scientific databases. The screening and selection of studies were performed by two independent reviewers, followed by validation by a third reviewer. Finally, the data were synthesized using a narrative approach. This review included 139 studies out of 789 search results. The most common use case of GANs was the synthesis of brain MRI images for data augmentation. GANs were also used to segment brain tumors and translate healthy images to diseased images or CT to MRI and vice versa. The included studies showed that GANs could enhance the performance of AI methods used on brain MRI imaging data. However, more efforts are needed to transform the GANs-based methods in clinical applications.
| S-EPMC9167371 | biostudies-literature
Project description:The large intra-class variance and small inter-class variance are the key factor affecting fine-grained image classification. Recently, some algorithms have been more accurate and efficient. However, these methods ignore the multi-scale information of the network, resulting in insufficient ability to capture subtle changes. To solve this problem, a weakly supervised fine-grained classification network based on multi-scale pyramid is proposed in this paper. It uses pyramid convolution kernel to replace ordinary convolution kernel in residual network, which can expand the receptive field of the convolution kernel and use complementary information of different scales. Meanwhile, the weakly supervised data augmentation network (WS-DAN) is used to prevent over fitting and improve the performance of the model. In addition, a new attention module, which includes spatial attention and channel attention, is introduced to pay more attention to the object part in the image. The comprehensive experiments are carried out on three public benchmarks. It shows that the proposed method can extract subtle feature and achieve classification effectively.
| S-EPMC8270455 | biostudies-literature
Project description:The constant demand for novel functional materials calls for efficient strategies to accelerate the materials discovery, and crystal structure prediction is one of the most fundamental tasks along that direction. In addressing this challenge, generative models can offer new opportunities since they allow for the continuous navigation of chemical space via latent spaces. In this work, we employ a crystal representation that is inversion-free based on unit cell and fractional atomic coordinates and build a generative adversarial network for crystal structures. The proposed model is applied to generate the Mg-Mn-O ternary materials with the theoretical evaluation of their photoanode properties for high-throughput virtual screening (HTVS). The proposed generative HTVS framework predicts 23 new crystal structures with reasonable calculated stability and band gap. These findings suggest that the generative model can be an effective way to explore hidden portions of the chemical space, an area that is usually unreachable when conventional substitution-based discovery is employed.
| S-EPMC7453563 | biostudies-literature
Project description:Architectured materials on length scales from nanometers to meters are desirable for diverse applications. Recent advances in additive manufacturing have made mass production of complex architectured materials technologically and economically feasible. Existing architecture design approaches such as bioinspiration, Edisonian, and optimization, however, generally rely on experienced designers' prior knowledge, limiting broad applications of architectured materials. Particularly challenging is designing architectured materials with extreme properties, such as the Hashin-Shtrikman upper bounds on isotropic elasticity in an experience-free manner without prior knowledge. Here, we present an experience-free and systematic approach for the design of complex architectured materials with generative adversarial networks. The networks are trained using simulation data from millions of randomly generated architectures categorized based on different crystallographic symmetries. We demonstrate modeling and experimental results of more than 400 two-dimensional architectures that approach the Hashin-Shtrikman upper bounds on isotropic elastic stiffness with porosities from 0.05 to 0.75.
| S-EPMC7182413 | biostudies-literature
Project description:Conventional paper currency and modern electronic currency are two important modes of transactions. In several parts of the world, conventional methodology has clear precedence over its electronic counterpart. However, the identification of forged currency paper notes is now becoming an increasingly crucial problem because of the new and improved tactics employed by counterfeiters. In this paper, a machine assisted system-dubbed DeepMoney-is proposed which has been developed to discriminate fake notes from genuine ones. For this purpose, state-of-the-art models of machine learning called Generative Adversarial Networks (GANs) are employed. GANs use unsupervised learning to train a model that can then be used to perform supervised predictions. This flexibility provides the best of both worlds by allowing unlabelled data to be trained on whilst still making concrete predictions. This technique was applied to Pakistani banknotes. State-of-the-art image processing and feature recognition techniques were used to design the overall approach of a valid input. Augmented samples of images were used in the experiments which show that a high-precision machine can be developed to recognize genuine paper money. An accuracy of 80% has been achieved. The code is available as an open source to allow others to reproduce and build upon the efforts already made.
| S-EPMC7924467 | biostudies-literature
Project description:PurposeComplementary information obtained from multiple contrasts of tissue facilitates physicians assessing, diagnosing and planning treatment of a variety of diseases. However, acquiring multiple contrasts magnetic resonance images (MRI) for every patient using multiple pulse sequences is time-consuming and expensive, where, medical image synthesis has been demonstrated as an effective alternative. The purpose of this study is to develop a unified framework for multimodal MR image synthesis.MethodsA unified generative adversarial network consisting of only a single generator and a single discriminator was developed to learn the mappings among images of four different modalities. The generator took an image and its modality label as inputs and learned to synthesize the image in the target modality, while the discriminator was trained to distinguish between real and synthesized images and classify them to their corresponding modalities. The network was trained and tested using multimodal brain MRI consisting of four different contrasts which are T1-weighted (T1), T1-weighted and contrast-enhanced (T1c), T2-weighted (T2), and fluid-attenuated inversion recovery (Flair). Quantitative assessments of our proposed method were made through computing normalized mean absolute error (NMAE), peak signal-to-noise ratio (PSNR), structural similarity index measurement (SSIM), visual information fidelity (VIF), and naturalness image quality evaluator (NIQE).ResultsThe proposed model was trained and tested on a cohort of 274 glioma patients with well-aligned multi-types of MRI scans. After the model was trained, tests were conducted by using each of T1, T1c, T2, Flair as a single input modality to generate its respective rest modalities. Our proposed method shows high accuracy and robustness for image synthesis with arbitrary MRI modality that is available in the database as input. For example, with T1 as input modality, the NMAEs for the generated T1c, T2, Flair respectively are 0.034 ± 0.005, 0.041 ± 0.006, and 0.041 ± 0.006, the PSNRs respectively are 32.353 ± 2.525 dB, 30.016 ± 2.577 dB, and 29.091 ± 2.795 dB, the SSIMs are 0.974 ± 0.059, 0.969 ± 0.059, and 0.959 ± 0.059, the VIF are 0.750 ± 0.087, 0.706 ± 0.097, and 0.654 ± 0.062, and NIQE are 1.396 ± 0.401, 1.511 ± 0.460, and 1.259 ± 0.358, respectively.ConclusionsWe proposed a novel multimodal MR image synthesis method based on a unified generative adversarial network. The network takes an image and its modality label as inputs and synthesizes multimodal images in a single forward pass. The results demonstrate that the proposed method is able to accurately synthesize multimodal MR images from a single MR image.
| S-EPMC7796974 | biostudies-literature
Project description:Conventional predictive Artificial Neural Networks (ANNs) commonly employ deterministic weight matrices; therefore, their prediction is a point estimate. Such a deterministic nature in ANNs causes the limitations of using ANNs for medical diagnosis, law problems, and portfolio management in which not only discovering the prediction but also the uncertainty of the prediction is essentially required. In order to address such a problem, we propose a predictive probabilistic neural network model, which corresponds to a different manner of using the generator in the conditional Generative Adversarial Network (cGAN) that has been routinely used for conditional sample generation. By reversing the input and output of ordinary cGAN, the model can be successfully used as a predictive model; moreover, the model is robust against noises since adversarial training is employed. In addition, to measure the uncertainty of predictions, we introduce the entropy and relative entropy for regression problems and classification problems, respectively. The proposed framework is applied to stock market data and an image classification task. As a result, the proposed framework shows superior estimation performance, especially on noisy data; moreover, it is demonstrated that the proposed framework can properly estimate the uncertainty of predictions.
| S-EPMC8471214 | biostudies-literature
Project description:The basic Generative Adversarial Networks (GAN) model is composed of the input vector, generator, and discriminator. Among them, the generator and discriminator are implicit function expressions, usually implemented by deep neural networks. GAN can learn the generative model of any data distribution through adversarial methods with excellent performance. It has been widely applied to different areas since it was proposed in 2014. In this review, we introduced the origin, specific working principle, and development history of GAN, various applications of GAN in digital image processing, Cycle-GAN, and its application in medical imaging analysis, as well as the latest applications of GAN in medical informatics and bioinformatics.
| S-EPMC7235323 | biostudies-literature
Project description:Automating medical diagnosis and training medical students with real-life situations requires the accumulation of large dataset variants covering all aspects of a patient's condition. For preventing the misuse of patient's private information, datasets are not always publicly available. There is a need to generate synthetic data that can be trained for the advancement of public healthcare without intruding on patient's confidentiality. Currently, rules for generating synthetic data are predefined and they require expert intervention, which limits the types and amount of synthetic data. In this paper, we propose a novel generative adversarial networks (GAN) model, named SynSigGAN, for automating the generation of any kind of synthetic biomedical signals. We have used bidirectional grid long short-term memory for the generator network and convolutional neural network for the discriminator network of the GAN model. Our model can be applied in order to create new biomedical synthetic signals while using a small size of the original signal dataset. We have experimented with our model for generating synthetic signals for four kinds of biomedical signals (electrocardiogram (ECG), electroencephalogram (EEG), electromyography (EMG), photoplethysmography (PPG)). The performance of our model is superior wheen compared to other traditional models and GAN models, as depicted by the evaluation metric. Synthetic biomedical signals generated by our approach have been tested while using other models that could classify each signal significantly with high accuracy.
| S-EPMC7761837 | biostudies-literature