Ontology highlight
ABSTRACT:
SUBMITTER: Nam H
PROVIDER: S-EPMC8663777 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Nam Hyeyoung H Kundu Anirban A Karki Suman S Brinkley Garrett J GJ Chandrashekar Darshan S DS Kirkman Richard L RL Liu Juan J Liberti Maria V MV Locasale Jason W JW Mitchell Tanecia T Varambally Sooryanarayana S Sudarshan Sunil S
JCI insight 20211122 22
Mounting evidence points to alterations in mitochondrial metabolism in renal cell carcinoma (RCC). However, the mechanisms that regulate the TCA cycle in RCC remain uncharacterized. Here, we demonstrate that loss of TCA cycle enzyme expression is retained in RCC metastatic tissues. Moreover, proteomic analysis demonstrates that reduced TCA cycle enzyme expression is far more pronounced in RCC relative to other tumor types. Loss of TCA cycle enzyme expression is correlated with reduced expression ...[more]