Ontology highlight
ABSTRACT:
SUBMITTER: Hsu R
PROVIDER: S-EPMC8664394 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Hsu Robert R Baca Yasmine Y Xiu Joanne J Wang Rongfu R Bodor J Nicholas JN Kim Chul C Khan Hina H Mamdani Hirva H Nagasaka Misako M Puri Sonam S Liu Stephen V SV Korn W Michael WM Nieva Jorge J JJ
Oncotarget 20211207 25
Cancer/testis antigens (CTAs) are strongly expressed in some solid tumors but minimally expressed in normal tissue, making them appealing therapeutic targets. KK-LC-1 (CXorf61) has cytoplasmic expression in gastric, breast, and lung cancer. We characterized the molecular subtypes of non-small cell lung cancer (NSCLC) expressing KK-LC-1 to inform rational clinical trials of T-cell receptor therapy (TCR-T) targeting KK-LC-1. 9790 NSCLC tumors that underwent whole transcriptome sequencing (Illumina ...[more]