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Capitate fracture nonunion in association with triquetrum avulsion fracture: Rare injury with massive effect on hand function, a case report.

ABSTRACT: Introduction and importance:Capitate fractures are rare and usually occur due to high-energy trauma. They are often associated with other wrist injuries or dislocations. An isolated occurrence of capitate and triquetral fractures due to high-energy trauma is rarely reported in the literature. This rare injury pattern has a significant effect on wrist function, as presented in this case. Case presentation:A 19-year-old male manual worker, presented with persistent right wrist pain and progressive loss of function after sustaining motor vehicle collision 5 months prior. The patient had major concerns regarding the return of wrist function. Clinical discussion:A diagnosis of collapsed capitate fracture nonunion associated with a triquetral avulsion fracture was made based on radiography, computed tomography (CT) scan, and magnetic resonance imaging (MRI). Treatment with internal fixation and strut corticocancellous autograft to restore capitate height resulted in substantial improvement in wrist function and alleviation of pain. The Mayo wrist score increased from 15/100 to 90/100 at the 6-year follow-up visit. Conclusion:Capitate fractures can occur in association with triquetral fractures in the absence of dislocation or greater arch injuries. Nonunion is a common complication, and internal fixation with bone graft is the gold standard for the treatment of capitate fracture nonunion, resulting in excellent outcomes and return of function.

SUBMITTER: Ar Altamimi A

PROVIDER: S-EPMC8666510 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:BackgroundNonunion is a failure of healing following a bone fracture. Its physiopathology remains partially unclear and the discovery of new mediators could promote the understanding of bone healing.MethodsThirty-three atrophic nonunion (NU) patients that failed to demonstrate any radiographic improvement for 6 consecutive months were recruited for providing serum samples. Thirty-five healthy volunteers (HV) served as the control group. Proteomics studies were performed using SELDI-TOF-MS and 2D-DIGE approaches, associated or not with Proteominer® preprocessing, to highlight biomarkers specific to atrophic nonunion pathology. Peak intensities were analyzed by two statistical approaches, a nonparametric Mann-Whitney U tests (univariate approach) and a machine-learning algorithm called extra-trees (multivariate approach). Validation of highlighted biomarkers was performed by alternative approaches such as microfluidic LC-MS/MS, nephelometry, western blotting or ELISA assays.ResultsFrom the 35 HV and 33 NU crude serum samples and Proteominer® eluates, 136 spectra were collected by SELDI-TOF-MS using CM10 and IMAC-Cu(2+) ProteinChip arrays, and 665 peaks were integrated for extra-trees multivariate analysis. Accordingly, seven biomarkers and several variants were identified as potential NU biomarkers. Their levels of expression were found to be down- or up-regulated in serum of HV vs NU. These biomarkers are inter-α-trypsin inhibitor H4, hepcidin, S100A8, S100A9, glycated hemoglobin β subunit, PACAP related peptide, complement C3 α-chain. 2D-DIGE experiment allowed to detect 14 biomarkers as being down- or up-regulated in serum of HV vs NU including a cleaved fragment of apolipoprotein A-IV, apolipoprotein E, complement C3 and C6. Several biomarkers such as hepcidin, complement C6, S100A9, apolipoprotein E, complement C3 and C4 were confirmed by an alternative approach as being up-regulated in serum of NU patients compared to HV controls.ConclusionTwo proteomics approaches were used to identify new biomarkers up- or down-regulated in the nonunion pathology, which are involved in bone turn-over, inflammation, innate immunity, glycation and lipid metabolisms. High expression of hepcidin or S100A8/S100A9 by myeloid cells and the presence of advanced glycation end products and complement factors could be the result of a longstanding inflammatory process. Blocking macrophage activation and/or TLR4 receptor could accelerate healing of fractured bone in at-risk patients.

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Capitate fracture nonunion in association with triquetrum avulsion fracture: Rare injury with massive effect on hand function, a case report.

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