Leveraging Heterogeneity in Systemic Lupus Erythematosus for New Therapies.
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ABSTRACT:
SUBMITTER: Allen ME
PROVIDER: S-EPMC8667782 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
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Leveraging Heterogeneity in Systemic Lupus Erythematosus for New Therapies.
Allen Marilyn E ME Rus Violeta V Szeto Gregory L GL
Trends in molecular medicine 20201009 2
Systemic lupus erythematosus (SLE) is a multisystem, chronic autoimmune disease where treatment varies by patient and disease activity. Strong preclinical results and clinical correlates have motivated development of many drugs, but many of these have failed to achieve efficacy in clinical trials. FDA approval of belimumab in 2011 was the first successful SLE drug in nearly six decades. In this article, we review insights into the molecular and clinical heterogeneity of SLE from transcriptomics ...[more]
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