Dataset Information

Low 30-day mortality and low carbapenem-resistance in a decade of Acinetobacter bacteraemia in South Sweden.

ABSTRACT:

Background

The aim of this study was to provide a descriptive account of carbapenem resistance and risk factors for mortality from invasive Acinetobacter infections in the south of Sweden.

Methods

Blood isolates with growth of Acinetobacter species between 2010 and 2019 in Skåne county were subtyped using MALDI-TOF and subjected to susceptibility testing against clinically relevant antibiotics. Association between risk factors and 30-day mortality were analysed in univariate and multivariate logistic regression models.

Results

There were 179 bacteraemia episodes in 176 patients included in the study. The 30-day all-cause mortality was 16%. In all, two percent of Acinetobacter strains were carbapenem resistant. Independent risk factors associated with 30-day mortality in the multivariate regression model were Acinetobacter growth in all blood cultures drawn at the day of bacteraemia onset (OR 5.0, 95% CI: 1.8 to 13.7, p= 0.002), baseline functional capacity (1-4 points, OR 2.0, 95% CI: 1.2 to 3.4, p= 0.010) and correct empiric antibiotics at time of culture (OR 3.5 95% CI: 1.0 to 11.8, p= 0.045).

Conclusion

This study on Acinetobacter bacteraemia in South Sweden found low 30-day mortality and low carbapenem-resistance rates compared to previous international studies which may be due to a higher rate of contaminant findings.

SUBMITTER: Ingefors E

PROVIDER: S-EPMC8667949 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

Low 30-day mortality and low carbapenem-resistance in a decade of <i>Acinetobacter</i> bacteraemia in South Sweden.

Ingefors Erik E Tverring Jonas J Nafaa Fatima F Jönsson Niklas N Karlsson Söbirk Sara S Kjölvmark Charlott C Ljungquist Oskar O

Infection ecology & epidemiology 20211210 1

<h4>Background</h4>The aim of this study was to provide a descriptive account of carbapenem resistance and risk factors for mortality from invasive <i>Acinetobacter</i> infections in the south of Sweden.<h4>Methods</h4>Blood isolates with growth of <i>Acinetobacter</i> species between 2010 and 2019 in Skåne county were subtyped using MALDI-TOF and subjected to susceptibility testing against clinically relevant antibiotics. Association between risk factors and 30-day mortality were analysed in un ...[more]

PMID: 34912503

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