Dataset Information

18F-THK5351 Positron Emission Tomography Imaging in Neurodegenerative Tauopathies.

ABSTRACT: Introduction: We aimed to determine whether in vivo tau deposits and monoamine oxidase B (MAO-B) detection using 18F-THK5351 positron emission tomography (PET) can assist in the differential distribution in patients with corticobasal syndrome (CBS), progressive supranuclear palsy (PSP), and Alzheimer's disease (AD) and whether 18F-THK5351 retention of lesion sites in CBS and PSP can correlate with clinical parameters. Methods: 18F-THK5351 PET was performed in 35 participants, including 7, 9, and 10 patients with CBS, PSP, and AD, respectively, and 9 age-matched normal controls. In CBS and PSP, cognitive and motor functions were assessed using the Montreal Cognitive Assessment, Addenbrooke's Cognitive Examination-Revised, and Frontal Assessment Battery, Unified Parkinson's Disease Rating Scale Motor Score, and PSP Rating Scale. Results: 18F-THK5351 retention was observed in sites susceptible to disease-related pathologies in CBS, PSP, and AD. 18F-THK5351 uptake in the precentral gyrus clearly differentiated patients with CBS from those with PSP and AD. Furthermore, 18F-THK5351 uptake in the inferior temporal gyrus clearly differentiated patients with AD from those with CBS and PSP. Regional 18F-THK5351 retention was associated with the cognitive function in CBS and PSP. Conclusion: Measurement of the tau deposits and MAO-B density in the brain using 18F-THK5351 may be helpful for the differential diagnosis of tauopathies and for understanding disease stages.

SUBMITTER: Ezura M

PROVIDER: S-EPMC8668184 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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18F-THK5351 Positron Emission Tomography Imaging in Neurodegenerative Tauopathies.

Ezura Michinori M Kikuchi Akio A Okamura Nobuyuki N Ishiki Aiko A Hasegawa Takafumi T Harada Ryuichi R Watanuki Shoichi S Funaki Yoshihito Y Hiraoka Kotaro K Baba Toru T Sugeno Naoto N Yoshida Shun S Kobayashi Junpei J Kobayashi Michiko M Tano Ohito O Ishiyama Shun S Nakamura Takaaki T Nakashima Ichiro I Mugikura Shunji S Iwata Ren R Taki Yasuyuki Y Furukawa Katsutoshi K Arai Hiroyuki H Furumoto Shozo S Tashiro Manabu M Yanai Kazuhiko K Kudo Yukitsuka Y Takeda Atsushi A Aoki Masashi M

Frontiers in aging neuroscience 20211129

Introduction: We aimed to determine whether in vivo tau deposits and monoamine oxidase B (MAO-B) detection using 18F-THK5351 positron emission tomography (PET) can assist in the differential distribution in patients with corticobasal syndrome (CBS), progressive supranuclear palsy (PSP), and Alzheimer's disease (AD) and whether 18F-THK5351 retention of lesion sites in CBS and PSP can correlate with clinical parameters. Methods: 18F-THK5351 PET ...[more]

PMID: 34912209

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Dataset Information

18F-THK5351 Positron Emission Tomography Imaging in Neurodegenerative Tauopathies.

Publications

<sup>18</sup>F-THK5351 Positron Emission Tomography Imaging in Neurodegenerative Tauopathies.

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