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Differential regulation of oxidative stress, microbiota-derived, and energy metabolites in the mouse brain during sleep.

ABSTRACT: Sleep has evolved as a universal core function to allow for restorative biological processes. Detailed knowledge of metabolic changes necessary for the sleep state in the brain is missing. Herein, we have performed an in-depth metabolic analysis of four mouse brain regions and uncovered region-specific circadian variations. Metabolites linked to oxidative stress were altered during sleep including acylcarnitines, hydroxylated fatty acids, phenolic compounds, and thiol-containing metabolites. These findings provide molecular evidence of a significant metabolic shift of the brain energy metabolism. Specific alterations were observed for brain metabolites that have previously not been associated with a circadian function including the microbiome-derived metabolite ergothioneine that suggests a regulatory function. The pseudopeptide β-citryl-glutamate has been linked to brain development and we have now discovered a previously unknown regioisomer. These metabolites altered by the circadian rhythm represent the foundation for hypothesis-driven studies of the underlying metabolic processes and their function.

SUBMITTER: Vallianatou T

PROVIDER: S-EPMC8669215 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Differential regulation of oxidative stress, microbiota-derived, and energy metabolites in the mouse brain during sleep.

Vallianatou Theodosia T Lin Weifeng W Bèchet Nicholas B NB Correia Mario Sp MS Shanbhag Nagesh C NC Lundgaard Iben I Globisch Daniel D

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20210722 12

Sleep has evolved as a universal core function to allow for restorative biological processes. Detailed knowledge of metabolic changes necessary for the sleep state in the brain is missing. Herein, we have performed an in-depth metabolic analysis of four mouse brain regions and uncovered region-specific circadian variations. Metabolites linked to oxidative stress were altered during sleep including acylcarnitines, hydroxylated fatty acids, phenolic compounds, and thiol-containing metabolites. The ...[more]

PMID: 34293940

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Dataset Information

Differential regulation of oxidative stress, microbiota-derived, and energy metabolites in the mouse brain during sleep.

Publications

Differential regulation of oxidative stress, microbiota-derived, and energy metabolites in the mouse brain during sleep.

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