Ontology highlight
ABSTRACT: Objective
To explore the effect of discontinuing continuous glucose monitoring (CGM) after 8 months of CGM use in adults with type 2 diabetes treated with basal without bolus insulin.Research design and methods
This multicenter trial had an initial randomization to either real-time CGM or blood glucose monitoring (BGM) for 8 months followed by 6 months in which the BGM group continued to use BGM (n = 57) and the CGM group was randomly reassigned either to continue CGM (n = 53) or discontinue CGM with resumption of BGM for glucose monitoring (n = 53).Results
In the group that discontinued CGM, mean time in range (TIR) 70-180 mg/dL, which improved from 38% before initiating CGM to 62% after 8 months of CGM, decreased after discontinuing CGM to 50% at 14 months (mean change from 8 to 14 months -12% [95% CI -21% to -3%], P = 0.01). In the group that continued CGM use, little change was found in TIR from 8 to 14 months (baseline 44%, 8 months 56%, 14 months 57%, mean change from 8 to 14 months 1% [95% CI -11% to 12%], P = 0.89). Comparing the two groups at 14 months, the adjusted treatment group difference in mean TIR was -6% (95% CI -16% to 4%, P = 0.20).Conclusions
In adults with type 2 diabetes treated with basal insulin who had been using real-time CGM for 8 months, discontinuing CGM resulted in a loss of about one-half of the initial gain in TIR that had been achieved during CGM use.
SUBMITTER: Aleppo G
PROVIDER: S-EPMC8669539 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Aleppo Grazia G Beck Roy W RW Bailey Ryan R Ruedy Katrina J KJ Calhoun Peter P Peters Anne L AL Pop-Busui Rodica R Philis-Tsimikas Athena A Bao Shichun S Umpierrez Guillermo G Davis Georgia G Kruger Davida D Bhargava Anuj A Young Laura L Buse John B JB McGill Janet B JB Martens Thomas T Nguyen Quang T QT Orozco Ian I Biggs William W Lucas K Jean KJ Polonsky William H WH Price David D Bergenstal Richard M RM
Diabetes care 20210929 12
<h4>Objective</h4>To explore the effect of discontinuing continuous glucose monitoring (CGM) after 8 months of CGM use in adults with type 2 diabetes treated with basal without bolus insulin.<h4>Research design and methods</h4>This multicenter trial had an initial randomization to either real-time CGM or blood glucose monitoring (BGM) for 8 months followed by 6 months in which the BGM group continued to use BGM (<i>n</i> = 57) and the CGM group was randomly reassigned either to continue CGM (<i> ...[more]