Stroke and Myocardial Infarction: A Bidirectional Mendelian Randomization Study.

ABSTRACT:

Background

Stroke and myocardial infarction (MI) are associated with each other, as demonstrated in observational studies. However, it is unclear whether this relationship is causal, and the purpose of this study was to explore the bidirectional causality between stroke and MI.

Methods

Causality between stroke and MI was assessed using two-sample Mendelian randomization (MR). All genetic instruments related to stroke (40,585 cases; 406,111 controls) and MI (43,676 cases; 128,199 controls) were derived from large published genome-wide association study. The MR analysis was calculated with inverse-variance weighting, MR-Egger, weighted mode, weighted median, and simple mode methods, and sensitivity analyses are used to detect the heterogeneity or pleiotropy.

Results

Gen

SUBMITTER: Sun W 

PROVIDER: S-EPMC8670204 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature