The role of vitamin D receptor gene polymorphisms in gestational diabetes mellitus susceptibility: a meta-analysis.

ABSTRACT: BACKGROUND:Gestational diabetes mellitus (GDM) is a common disease during pregnancy. The association of vitamin D receptor (VDR) polymorphisms with GDM is still controversial. This study aimed to assess the associations between VDR polymorphisms and GDM risk. METHODS:We searched Cochrane Library, PubMed, and Embase electronic database for all eligible studies published from Jan 1, 1980 to December 31, 2020 to conduct a Meta-analysis. We analyzed four VDR polymorphisms: BsmI (rs1544410), ApaI (rs7975232), TaqI (rs731236), and FokI (rs2228570). INCLUSION CRITERIA:(1) The data can be evaluated; (2) case-control study; and (3) meeting the Hardy-Weinberg's law. EXCLUSION CRITERIA:(1) Insufficient or extractable data; (2) Severe publication bias in the data; and (3) duplicate publications. We ev

SUBMITTER: Liu S 

PROVIDER: S-EPMC8670261 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature