Identifying and characterizing lincRNA genomic clusters reveals its cooperative functions in human cancer.

ABSTRACT:

Background

Emerging evidence has revealed that some long intergenic non-coding RNAs (lincRNAs) are likely to form clusters on the same chromosome, and lincRNA genomic clusters might play critical roles in the pathophysiological mechanism. However, the comprehensive investigation of lincRNA clustering is rarely studied, particularly the characterization of their functional significance across different cancer types.

Methods

In this study, we firstly constructed a computational method basing a sliding window approach for systematically identifying lincRNA genomic clusters. We then dissected these lincRNA genomic clusters to identify common characteristics in cooperative expression, conservation among divergent species, targeted miRNAs, and CNV frequency. Next, we performed com

SUBMITTER: Zhou H 

PROVIDER: S-EPMC8672572 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature