Defining Clinical Subgroups in Relapsing Polychondritis: A Prospective Observational Cohort Study.

ABSTRACT:

Objective

Relapsing polychondritis (RP) is a systemic disease. Failure to recognize RP can lead to diagnostic delay and further complications, including death. This study was undertaken to identify clinical patterns in a prospective cohort of patients with RP.

Methods

Patient subgroups were identified using latent class analysis based on 8 clinical variables: saddle-nose deformity, subglottic stenosis, tracheomalacia, bronchomalacia, ear chondritis, tenosynovitis/synovitis, inflammatory eye disease, and audiovestibular disease. Model selection was based on Akaike's information criterion.

Results

Seventy-three patients were included in this study. Patients were classified into 1 of 3 subgroups: type 1 RP (14%), type 2 RP (29%), and type 3 RP (58%). Type 1 RP was charac

SUBMITTER: Ferrada M 

PROVIDER: S-EPMC8672710 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature