Browse
Submit Data
Databases
API
Help

Dataset Information

23 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Somatic mutations and CRISPR/Cas9 library screening integrated analysis identifies cervical cancer drug-resistant pathways.

ABSTRACT:

SUBMITTER: Cao C

PROVIDER: S-EPMC8673421 | biostudies-literature |

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Similar Datasets

Genome-wide CRISPR/Cas9 library screening identifies genes regulating the IFN signalling pathways.

Project description:Innate immunity is a non-specific host immune response against pathogen invasion. It exists widely in most of cells and is considered as the first line of defense against pathogen infection. Upon virus infection, the natural immune system is activated to generate immune response, thereby exerting the antiviral effect and effectively inhibiting the spread of virus in the body. With recent decades of research, people have found and identified the key regulatory factors of the natural immune response and the signal transduction. However the regulatory mechanisms of the factors are still unclear and need to be further explored. Our work used the CRISPR/Cas9 library to perform large-scale genome-wide, unbiased screening in immune cells, and discovered some novel genes involved in the regulation of type I IFN responses.

2020-01-11 | GSE143467 | GEO

Genome-wide CRISPR/Cas9 library screening identifies genes regulating the IFN signalling pathways.

Project description:Genome-wide CRISPR/Cas9 library screening identifies genes regulating the IFN signalling pathways.

| PRJNA600543 | ENA

Minimal genome-wide human CRISPR-Cas9 library.