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GENOMIC CHARACTERIZATION OF SARS-CoV-2 AND ITS ASSOCIATION WITH CLINICAL OUTCOMES: A ONE-YEAR LONGITUDINAL STUDY OF THE PANDEMIC IN COLOMBIA.

ABSTRACT:

Objectives

This study aims to explore the association between the molecular characterization of SARS-CoV-2 and disease severity on ambulatory and hospitalized patients in two main Colombian epicenters during the first year of the COVID-19 pandemic.

Methods

We included 1000 patients with SARS-CoV-2 infection, collected clinical data from 997, and obtained 678 whole genome sequences by massively parallel sequencing. Bivariate, multivariate, and classification and regression tree analyses were run between clinical and genomic variables.

Results

Age and infection with lineages B.1.1, B.1.1.388, B.1.523, and B.1.621 were related to lethality for patients 71-88 years old (OR: 6.048036; 95% CI 1.346567-32.92521, p-value: 0.01718674). The need for hospitalization was associated with higher age and comorbidities. For patients 38-51 years old infected with lineages A, B, B.1.1.388, B.1.1.434, B.1.153, B.1.36.10, B.1.411, B.1.471, B.1.558 or B.1.621, hospitalization rate increased significantly (OR 8.368427, 95% CI 2.573145-39.10672, p-value: 0.00012). Associations between clades and clinical outcomes diverged from previously reported data.

Conclusions

Lineage B.1.621 increased the need for hospitalization and lethality. Our findings, plus the rapidly increasing prevalence in Colombia and other countries, suggest broadly considering it as a Variant of Interest. If associated disease severity is confirmed, possible designation as Variant of Concern could be entertained.

SUBMITTER: Ruiz-Sternberg AM

PROVIDER: S-EPMC8673727 | biostudies-literature |

REPOSITORIES: biostudies-literature

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