The genetic architecture of human cortical folding.
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ABSTRACT:
SUBMITTER: van der Meer D
PROVIDER: S-EPMC8673767 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Publications
The genetic architecture of human cortical folding.
van der Meer Dennis D Kaufmann Tobias T Shadrin Alexey A AA Makowski Carolina C Frei Oleksandr O Roelfs Daniel D Monereo-Sánchez Jennifer J Linden David E J DEJ Rokicki Jaroslav J Alnæs Dag D de Leeuw Christiaan C Thompson Wesley K WK Loughnan Robert R Fan Chun Chieh CC Westlye Lars T LT Andreassen Ole A OA Dale Anders M AM
Science advances 20211215 51
The folding of the human cerebral cortex is a highly genetically regulated process that allows for a much larger surface area to fit into the cranial vault and optimizes functional organization. Sulcal depth is a robust yet understudied measure of localized folding, previously associated with multiple neurodevelopmental disorders. Here, we report the first genome-wide association study of sulcal depth. Through the multivariate omnibus statistical test (MOSTest) applied to vertex-wise measures fr ...[more]
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