Misexpression of genes lacking CpG islands drives degenerative changes during aging.
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ABSTRACT:
SUBMITTER: Lee JY
PROVIDER: S-EPMC8673774 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Publications
Misexpression of genes lacking CpG islands drives degenerative changes during aging.
Lee Jun-Yeong JY Davis Ian I Youth Elliot H H EHH Kim Jonghwan J Churchill Gary G Godwin James J Korstanje Ron R Beck Samuel S
Science advances 20211215 51
Cellular aging is characterized by disruption of the nuclear lamina and its associated heterochromatin. How these structural changes within the nucleus contribute to age-related degeneration of the organism is unclear. Genes lacking CpG islands (CGI<sup>−</sup> genes) generally associate with heterochromatin when they are inactive. Here, we show that the expression of these genes is globally activated in aged cells and tissues. This CGI<sup>−</sup> gene misexpression is a common feature of norma ...[more]
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