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Ultrasmall PEI-Decorated Bi₂Se₃ Nanodots as a Multifunctional Theranostic Nanoplatform for in vivo CT Imaging-Guided Cancer Photothermal Therapy.

ABSTRACT: Bi-based nanomaterials, such as Bi₂Se₃, play an important part in biomedicine, such as photothermal therapy (PTT) and computed tomography (CT) imaging. Polyethylenimine (PEI)-modified ultrasmall Bi₂Se₃ nanodots were prepared using an ultrafast synthetic method at room temperature (25°C). Bi₂Se₃ nanodots exhibited superior CT imaging performance, and could be used as effective photothermal reagents owing to their broad absorption in the ultraviolet-visible-near infrared region. Under irradiation at 808 nm, PEI-Bi₂Se₃ nanodots exhibited excellent photothermal-conversion efficiency of up to 41.3%. Good biocompatibility and significant tumor-ablation capabilities were demonstrated in vitro and in vivo. These results revealed that PEI-Bi₂Se₃ nanodots are safe and a good nanotheranostic platform for CT imaging-guided PTT of cancer.

SUBMITTER: Zhang P

PROVIDER: S-EPMC8675356 | biostudies-literature |

REPOSITORIES: biostudies-literature

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