Associations between inflammation, cardiovascular biomarkers and incident frailty: the British Regional Heart Study.

ABSTRACT:

Introduction

cardiovascular disease (CVD) and chronic inflammation are implicated in the development of frailty. Longitudinal analyses of inflammatory markers, biomarkers of cardiac dysfunction and incidence of frailty are limited.

Methods

in the British Regional Heart Study, 1,225 robust or pre-frail men aged 71-92 years underwent a baseline examination, with questionnaire-based frailty assessment after 3 years. Frailty definitions were based on the Fried phenotype. Associations between incident frailty and biomarkers of cardiac dysfunction (high-sensitivity cardiac troponin T (hs-cTnT), N-terminal pro B-type natriuretic peptide (NT-proBNP)) and inflammation (C-reactive protein (CRP) and interleukin-6 (IL-6)) were examined, by tertile, with the lowest as reference.

Resul

SUBMITTER: McKechnie DGJ 

PROVIDER: S-EPMC8675445 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature