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Novel feature extraction method for signal analysis based on independent component analysis and wavelet transform.

ABSTRACT: Feature extraction is an important part of data processing that provides a basis for more complicated tasks such as classification or clustering. Recently many approaches for signal feature extraction were created. However, plenty of proposed methods are based on convolutional neural networks. This class of models requires a high amount of computational power to train and deploy and large dataset. Our work introduces a novel feature extraction method that uses wavelet transform to provide additional information in the Independent Component Analysis mixing matrix. The goal of our work is to combine good performance with a low inference cost. We used the task of Electrocardiography (ECG) heartbeat classification to evaluate the usefulness of the proposed approach. Experiments were carried out with an MIT-BIH database with four target classes (Normal, Vestibular ectopic beats, Ventricular ectopic beats, and Fusion strikes). Several base wavelet functions with different classifiers were used in experiments. Best was selected with 5-fold cross-validation and Wilcoxon test with significance level 0.05. With the proposed method for feature extraction and multi-layer perceptron classifier, we obtained 95.81% BAC-score. Compared to other literature methods, our approach was better than most feature extraction methods except for convolutional neural networks. Further analysis indicates that our method performance is close to convolutional neural networks for classes with a limited number of learning examples. We also analyze the number of required operations at test time and argue that our method enables easy deployment in environments with limited computing power.

SUBMITTER: Topolski M

PROVIDER: S-EPMC8675669 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:The discovery and characterization of blood-based disease biomarkers are clinically important because blood collection is easy and involves relatively little stress for the patient. However, blood generally reflects not only targeted diseases, but also the whole body status of patients. Thus, the selection of biomarkers may be difficult. In this study, we considered miRNAs as biomarker candidates for several reasons. First, since miRNAs were discovered relatively recently, they have not yet been tested extensively. Second, since the number of miRNAs is relatively limited, selection is expected to be easy. Third, since they are known to play critical roles in a wide range of biological processes, their expression may be disease specific. We applied a newly proposed method to select combinations of miRNAs that discriminate between healthy controls and each of 14 diseases that include 5 cancers. A new feature selection method is based on principal component analysis. Namely this method does not require knowledge of whether each sample was derived from a disease patient or a healthy control. Using this method, we found that hsa-miR-425, hsa-miR-15b, hsa-miR-185, hsa-miR-92a, hsa-miR-140-3p, hsa-miR-320a, hsa-miR-486-5p, hsa-miR-16, hsa-miR-191, hsa-miR-106b, hsa-miR-19b, and hsa-miR-30d were potential biomarkers; combinations of 10 of these miRNAs allowed us to discriminate each disease included in this study from healthy controls. These 12 miRNAs are significantly up- or downregulated in most cancers and other diseases, albeit in a cancer- or disease-specific combinatory manner. Therefore, these 12 miRNAs were also previously reported to be cancer- and disease-related miRNAs. Many disease-specific KEGG pathways were also significantly enriched by target genes of up-/downregulated miRNAs within several combinations of 10 miRNAs among these 12 miRNAs. We also selected miRNAs that could discriminate one disease from another or from healthy controls. These miRNAs were found to be largely overlapped with miRNAs that discriminate each disease from healthy controls.

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Novel feature extraction method for signal analysis based on independent component analysis and wavelet transform.

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