Dopamine Neuron Challenge Test for early detection of Parkinson's disease.
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ABSTRACT:
SUBMITTER: Zhou J
PROVIDER: S-EPMC8677804 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Publications
Dopamine Neuron Challenge Test for early detection of Parkinson's disease.
Zhou Jingheng J Li Jicheng J Papaneri Amy B AB Kobzar Nicholas P NP Cui Guohong G
NPJ Parkinson's disease 20211216 1
Diagnosing Parkinson's disease (PD) before the clinical onset proves difficult because the hallmark PD symptoms do not manifest until more than 60% of dopamine neurons in the substantia nigra pars compacta have been lost. Here we show that, by evoking a transient dopamine release and subsequently measuring the levels of dopamine metabolites in the cerebrospinal fluid and plasma, a hypodopaminergic state can be revealed when less than 30% of dopamine neurons are lost in mouse PD models. These fin ...[more]
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