Ontology highlight
ABSTRACT:
SUBMITTER: Lee SH
PROVIDER: S-EPMC8682945 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Lee Sze-Hwei SH Lin Chien-Chin CC Wei Chao-Hong CH Chang Ko-Ping KP Yuan Chang-Tsu CT Tsai Cheng-Hong CH Liu Jia-Hao JH Hou Hsin-An HA Tang Jih-Lu JL Chou Wen-Chien WC Tien Hwei-Fang HF
The journal of pathology. Clinical research 20210904 1
Myeloproliferative neoplasms (MPNs) are characterized by upregulation of proinflammatory cytokines and immune dysregulation, which provide a reasonable basis for immunotherapy in patients. Megakaryocytes are crucial in the pathogenesis of primary myelofibrosis (PMF), the most clinically aggressive subtype of MPN. In this study, we aimed to explore PD-L1 (programmed death-ligand 1) expression in megakaryocytes and its clinical implications in PMF. We analyzed PD-L1 expression on megakaryocytes in ...[more]