Molecular self-avoidance in synaptic neurexin complexes.
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ABSTRACT:
SUBMITTER: Wang CY
PROVIDER: S-EPMC8682996 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Publications
Molecular self-avoidance in synaptic neurexin complexes.
Wang Cosmos Yuqi CY Trotter Justin H JH Liakath-Ali Kif K Lee Sung-Jin SJ Liu Xinran X Südhof Thomas C TC
Science advances 20211217 51
Synapses are thought to be organized by interactions of presynaptic neurexins with postsynaptic ligands, particularly with neuroligins and cerebellins. However, when a neuron forms adjacent pre- and postsynaptic specializations, as in dendrodendritic or axo-axonic synapses, nonfunctional cis neurexin/ligand interactions would be energetically favored. Here, we reveal an organizational principle for preventing synaptic cis interactions (“self-avoidance”). Using dendrodendritic synapses between mi ...[more]
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