Noradrenergic terminal short-term potentiation enables modality-selective integration of sensory input and vigilance state.
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ABSTRACT:
SUBMITTER: Gray SR
PROVIDER: S-EPMC8682997 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
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Noradrenergic terminal short-term potentiation enables modality-selective integration of sensory input and vigilance state.
Gray Shawn R SR Ye Liang L Ye Jing Yong JY Paukert Martin M
Science advances 20211217 51
Recent years have seen compelling demonstrations of the importance of behavioral state on sensory processing and attention. Arousal plays a dominant role in controlling brain-wide neural activity patterns, particularly through modulation by norepinephrine. Noradrenergic brainstem nuclei, including locus coeruleus, can be activated by stimuli of multiple sensory modalities and broadcast modulatory signals via axonal projections throughout the brain. This organization might suggest proportional br ...[more]
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