Efficacy and Adverse Effects of Atropine for Myopia Control in Children: A Meta-Analysis of Randomised Controlled Trials.

ABSTRACT:

Objectives

To explore the rebound effects and safety of atropine on accommodation amplitude in slowing myopia progression.

Methods

We conducted a meta-analysis to testify proper dosage of atropine in children with myopia. We searched in PubMed, EMBASE, Ovid, and the Cochrane Library up to March 30, 2021. We selected randomised controlled trials (RCTs) that evaluated the efficacy of atropine for controlling myopia progression in children. We performed the inverse variance random-effects model to pool the data using mean difference (MD) for continuous variables. Statistical heterogeneity was assessed using the I² test. Additionally, we conducted subgroup analyses and sensitivity analyses.

Results

Seventeen RCTs involving 2955 participants were included. Myopi

SUBMITTER: Chen C 

PROVIDER: S-EPMC8683246 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature