Comprehensive Analysis to Identify Key Genes Involved in Advanced Atherosclerosis.

ABSTRACT:

Background

The study was aimed at finding accurate and effective therapeutic targets and deepening our understanding of the mechanisms of advanced atherosclerosis (AA).

Methods

We downloaded the gene expression datasets GSE28829, GSE120521, and GSE43292 from Gene Expression Omnibus. Weighted gene coexpression network analysis (WGCNA) was performed for GSE28829, and functional enrichment analysis and protein-protein interaction network analysis were conducted on the key module. Significant genes in the key module were analyzed by molecular complex detection, and genes in the most important subnetwork were defined as hub genes. Multiple dataset analyses for hub genes were conducted. Genes that overlapped between hub genes and differentially expressed genes (DEGs) of GSE28829 a

SUBMITTER: Huo TM 

PROVIDER: S-EPMC8683248 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature