Overemphasis on recovery inhibits community transformation and creates resilience traps.
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ABSTRACT:
SUBMITTER: Rachunok B
PROVIDER: S-EPMC8683504 | biostudies-literature |
REPOSITORIES: biostudies-literature
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Project description:Background and aimsSoil degradation is a major global problem; to investigate the potential for recovery of soil biota and associated key functions, soils were monitored during the early years of conversion between permanent grassland, arable cropping and bare fallow (maintained by regular tilling). Distinct differences in soil properties had become apparent 50 years after a previous conversion.MethodsSubplots on previously permanent grassland, arable and bare fallow soil were converted to the two alternatives, generating 9 treatments. Soil properties (soil organic carbon, mesofauna, microbial community structure and activity) were measured.ResultsAfter 2 years, mesofauna and microbial abundance increased where plants were grown on previously bare fallow soils and declined where grassland was converted to bare fallow treatment. Overall prokaryote community composition remained more similar to the previous treatments of the converted plots than to the new treatments but there were significant changes in the relative abundance of some groups and functional genes. Four years after conversion, SOC in arable and bare fallow soils converted to grassland had increased significantly.ConclusionsConversion to permanent grassland effectively replenished C in previously degraded soil; the soil microbiome showed significant conversion-related changes; plant-driven recovery was quicker than C loss in the absence of plants.
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Project description:This study examines the hypothesis that social capital can be a foundation for community disaster resilience with an analysis of empirical findings from the August 2018 earthquake recovery on Gili Trawangan, Indonesia, a globally known coastal tourism destination. Positive links between community social capital and community disaster resilience are hypothesized, but the extent to which an iterative and interdependent relationship is co-shaping both is less understood. Social capital can enable collective action, providing self-organized social, psychological, financial and material resources following a disaster, that may otherwise need to be provided externally. In turn, disasters create collective action problems where collective response and recovery process are needed, creating an institutional space where the degree of usefulness, meaning and function of social capital can be shaped, recognized and drawn upon, often where external aid is insufficient. These relationships can be observed following disasters, because individuals and communities are often linked through emotive and meaningful sequences of common experiences, actions and activities. Findings descriptively detail Gili Trawangan's response and recovery process through the events and activities that occurred, and are then theoretically analyzed with a social capital framework including bonding (within group), bridging (between group) and linking (across power and institutional) ties. Three conclusions can be summarized. (1) Community social capital and disaster resilience are iteratively co-shaped through collective experiences, actions and activities. (2) Understanding context is critical for understanding if and to what degree this relationship exists. (3) The mechanism through which social capital enhances resilience is that it can enable collective action that can lead to the provision of needed aid and services.
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Project description:Iceland's fisheries system is well-governed, data-rich, and has adapted to past ecological change. It thus provides an opportunity to identify social-ecological attributes of climate resilience and interactions among them. We elicited barriers and enabling conditions for adaptation in Iceland's fisheries from semi-structured expert interviews, using projections of fish habitat shifts by mid-century to guide discussion. Interviewees highlighted flexible management, highly connected institutions that facilitate learning, ample assets to expand adaptive options, and cultural comfort with change. However, examining how these attributes interact in reinforcing feedback loops revealed potential rigidity traps, where optimization for resilience to stock shifts may render the system more vulnerable to extreme environmental change and social backlash. This study articulates resilience attributes that Iceland and other fisheries systems might prioritize as the climate changes. It further explores circumstances in which these same attributes risk forming traps, and potential pathways to escape them.
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Project description:Researchers generally agree that communities should participate in the community-based research process, but neither a universally accepted approach to community participation nor a set of guiding principles exists.The Morehouse School of Medicine Prevention Research Center was established in 1999 with the support of a grant from the Centers for Disease Control and Prevention. Its partners include a low-income, predominantly African American community, six public agencies, and two other academic institutions. A Community Coalition Board was established to represent the partners. The majority of the board is community members; it serves in a governance rather than an advisory capacity, with the community acting as the senior partner in interactions with the medical school, the agencies, and other academic institutions.The Community Coalition Board developed a set of research priorities and a set of 10 community values, or principles, to guide research. A board committee reviews each protocol to ensure they uphold the values.The Community Coalition Board has been using the values since 1999, and in this article we describe its experience. After an initial period that included some disagreements between researchers and community members on the board, relationships have been good, and protocols have been approved with only minor changes.Although the established community values reflect universally acknowledged principles of research ethics, they also address local concerns. An equal partnership between community members and researchers is most beneficial if the partners can agree on a set of values to govern research.
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Project description:Based on data from A-share listed companies from 2007 to 2021, this study constructs an enterprise resilience index using the entropy-weighted TOPSIS method. On this basis, the impact of digital transformation on enterprise resilience is examined through empowerment theory. The empirical results indicate that digital transformation significantly enhances enterprise resilience, a conclusion that remains valid after a series of robustness tests. Mechanism analysis reveals that digital transformation enhances enterprise resilience by reducing agency costs, increasing information transparency, and alleviating financing constraints. Heterogeneity analysis shows that micro-characteristics of enterprises, such as the stage of the life cycle and factor intensity, as well as macro-environmental factors like regional intellectual property rights protection and industry competition level, have differential impacts on the resilience-enhancing effects of digital transformation. Further analysis suggests that the level of corporate governance influences the positive impact of digital transformation on enterprise resilience.
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Project description:Neutrophil extracellular traps (NETs) contribute to inflammatory pathogenesis, especially in infectious and cardiovascular diseases. H2 gas acts as an antioxidant and has been clinically and experimentally proven to ameliorate inflammation. Therefore, we investigated whether H2 gas could inhibit NET formation associated with excessive neutrophil activation. Phorbol-12-myristate-13-acetate (PMA)-stimulated human neutrophils exposed to H2 exhibited reduced citrullination of histones, membrane disruption by chromatin complexes, and release of NET components over controls. Mechanistically, H2 suppressed the phosphorylation of Ser-139 residue in H2AX, a marker of DNA damage, thereby reducing the expression of CXC-chemokine receptor 4 (CXCR4) in PMA-stimulated neutrophils. Along with the upregulation of CXCR4, the intracellular content of myeloperoxidase (MPO) and the production of MPO-derived hypochlorous acid (HOCl) was increased; however, these effects were markedly suppressed in H2-exposed cultures. Thus, H2 neutralized HOCl produced by the oxidative burst, inhibited DNA damage, and subsequently inhibited NET formation. We further confirmed that inhalation of H2 inhibited the formation and release of NET components in the blood and bronchoalveolar lavage of a lipopolysaccharide-induced sepsis model in mice and aged minipigs. Therefore, H2 therapy has the potential to be a new therapeutic agent for inflammatory diseases involving NETs associated with excessive neutrophil activation.
2022-02-23 | GSE178883 | GEO
Project description:sh RNA of p73 in Fibroblasts compared to non-silencing control Keywords: cell growth, shRNA, p73
2008-04-01 | GSE7201 | GEO
Project description:BACKGROUND AND AIMS:Resilience and recovery are of increasing importance in the field of alcohol dependence (AD). This paper describes how imaging studies in man can be used to assess the neurobiological correlates of resilience and, if longitudinal, of disease trajectories, progression rates and markers for recovery to inform treatment and prevention options. METHODS:Original papers on recovery and resilience in alcohol addiction and its neurobiological correlates were identified from PubMed and have been analyzed and condensed within a systematic literature review. RESULTS:Findings deriving from functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) studies have identified links between increased resilience and less task-elicited neural activation within the basal ganglia, and benefits of heightened neural pre-frontal cortex (PFC) engagement regarding resilience in a broader sense; namely, resilience against relapse in early abstinence of AD. Furthermore, findings consistently propose at least partial recovery of brain glucose metabolism and executive and general cognitive functioning, as well as structural plasticity effects throughout the brain of alcohol-dependent patients during the course of short-, medium- and long-term abstinence, even when patients only lowered their alcohol consumption to a moderate level. Additionally, specific factors were found that appear to influence these observed brain recovery processes in AD, e.g. genotype-dependent neuronal (re)growth, gender-specific neural recovery effects, critical interfering effects of psychiatric comorbidities, additional smoking or marijuana influences or adolescent alcohol abuse. CONCLUSIONS:Neuroimaging research has uncovered neurobiological markers that appear to be linked to resilience and improved recovery capacities that are furthermore influenced by various factors such as gender or genetics. Consequently, future system-oriented approaches may help to establish a broad neuroscience-based research framework for alcohol dependence.
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Project description:The novel coronavirus pandemic has currently emerged as the world's worst disaster in history whose nature of cause is still under debate. Community in the current study refers to group of people subjected to common risks or threats and with the capacity to recognize disruptive events. Disaster sociologists have a common consensus that these communities should be directly involved in planning and preparing for response to disaster, mitigating effects, thus reducing its risk through Community-based Disaster Management (CBDM) strategy. A community approach can help in assessing levels of disaster risk in advance and also enhances the social capacity of preparedness, response, and recovery. In the current study, analysis of such programs and strategies are presented in which community participates in disaster resilience. Various case studies of disaster risk management policies are adapted by Asian countries. Role of faith-based organizations working for disaster management and mitigation is discussed in the present study.
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