Dataset Information

The first nosocomial cluster of COVID-19 due to the Delta variant in a major acute-care hospital in Singapore - investigations and outbreak response.

ABSTRACT:

Objectives

The first large nosocomial cluster of COVID-19 in Singapore in April 2021 led to partial closure of a major acute-care hospital. We report our investigations and evaluate the effectiveness of the BNT162.b2 and mRNA1273 vaccines against the Delta variant.

Methods

Close contacts of COVID-19 patients and the affected ward were identified and underwent surveillance for SARS-CoV-2 infection. Patient, staff and visitor cohorts were constructed and factors associated with infection evaluated. Phylogenetic analysis of patient samples was performed. Ward air exhaust filters were tested for SARS-CoV-2 virus.

Results

There were 47 cases in total, comprising 29 patients, 9 staff, 6 ward visitors and 3 household contacts. All infections were of the Delta variant. Ventilation studies showed turbulent airflow and swabs from air exhaust filters were positive for SARS-Cov2. Vaccine breakthrough infections were seen in both patients and staff. Among patients, vaccination was associated with a 79% lower odds of infection with COVID-19 (adjusted OR =0.21, 95%CI 0.05-0.95) CONCLUSIONS: This cluster occurred despite an enhancement in infection control measures that the hospital had undertaken at the onset of this pandemic, but it was rapidly brought under control through case isolation, extensive contact tracing and quarantine measures, and led to enhancements in hospital personal protective equipment (PPE) use, introduction of routine rostered testing of inpatients and staff, and hospital infrastructure changes to improve ventilation within the general ward.

SUBMITTER: Lim WY

PROVIDER: S-EPMC8687717 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:Waning humoral immunity after mRNA vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a significant problem for public health. Breakthrough infection in hospitals over several months after vaccination has not been fully characterized, especially against the delta (B.1.617.2) variant. Here, we describe an outbreak in our hospital in September of 2021, mainly through serological evaluation of the breakthrough infection. This retrospective observational study was done at an emergency and acute care hospital with 204 beds and 486 staff members where most staff members (92.6%) had had their second BNT162b2 vaccination by May of 2021. The peri-infection anti-spike RBD protein IgG (anti-S IgG) titers (lowest values between 11 days before and 7 days after onset or diagnosis) of serum samples from the breakthrough-infected persons were quantified. We also logarithmically estimated the anti-S IgG titers during the exposure period in September of uninfected staff members from their samples collected in May and December 2021. Whole-genome sequencing was done on obtained samples. In this outbreak, twelve persons (ten inpatients and two staff members) were diagnosed with SARS-CoV-2 infection by Loop-Mediated Isothermal Amplification (LAMP) or RT-PCR, eight of whom had been vaccinated twice. Peri-infection anti-S IgG titers could be determined in seven of the eight breakthrough cases, with a geometric mean titer (GMT) of 1,034 AU/ml (95% confidence interval [CI], 398 to 2,686). Among 289 uninfected staff members with data from the two sampling points, the GMT of the estimated anti-S IgG titers during the exposure period in 51 staff members, who were working at the outbreak ward and potentially exposed but uninfected, and 238 other unexposed staff members were 1,458 AU/ml (95% CI, 1,196 to 1,777) and 1,628 AU/ml (95% CI, 1,500 to 1,766), respectively. All viruses from the eight samples for which whole-genome sequencing was available were identified as delta variants. Of the infected persons, one remained asymptomatic throughout the course of treatment, and eleven had an illness of mild to moderate severity, including ten who received monoclonal antibody cocktail (Casirivimab/imdevimab) therapy. Measurement and estimation of anti-spike antibody levels after SARS-CoV-2 vaccination would be helpful for evaluating the risk of breakthrough infection and for determining the necessity of booster vaccination.