Acute Cortisol Profile Associations With Cognitive Impairment After Severe Traumatic Brain Injury.

ABSTRACT:

Background

Cognitive impairments commonly occur after traumatic brain injury (TBI) and affect daily functioning. Cortisol levels, which are elevated during acute hospitalization for most individuals after severe TBI, can influence cognition, but this association has not been studied previously in TBI.

Objective

We hypothesized that serum and cerebral spinal fluid (CSF) cortisol trajectories over days 0-5 post-injury are associated with cognition 6-month post-injury.

Methods

We examined 94 participants with severe TBI, collected acute serum and/or CSF samples over days 0-5 post-injury, and compared cortisol levels to those in 17 healthy controls. N = 88 participants had serum, and n = 84 had CSF samples available for cortisol measurement and had neuropsychological test

SUBMITTER: Barton DJ 

PROVIDER: S-EPMC8688285 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature