Dataset Information

Histogram analysis of tensor-valued diffusion MRI in meningiomas: Relation to consistency, histological grade and type.

ABSTRACT:

Background

Preoperative radiological assessment of meningioma characteristics is of value for pre- and post-operative patient management, counselling, and surgical approach.

Purpose

To investigate whether tensor-valued diffusion MRI can add to the preoperative prediction of meningioma consistency, grade and type.

Materials and methods

30 patients with intracranial meningiomas (22 WHO grade I, 8 WHO grade II) underwent MRI prior to surgery. Diffusion MRI was performed with linear and spherical b-tensors with b-values up to 2000 s/mm². The data were used to estimate mean diffusivity (MD), fractional anisotropy (FA), mean kurtosis (MK) and its components-the anisotropic and isotropic kurtoses (MK_A and MK_I). Meningioma consistency was estimated for 16 patients during resection based on ultrasonic aspiration intensity, ease of resection with instrumentation or suction. Grade and type were determined by histopathological analysis. The relation between consistency, grade and type and dMRI parameters was analyzed inside the tumor ("whole-tumor") and within brain tissue in the immediate periphery outside the tumor ("rim") by histogram analysis.

Results

Lower 10th percentiles of MK and MK_A in the whole-tumor were associated with firm consistency compared with pooled soft and variable consistency (n = 7 vs 9; U test, p = 0.02 for MK_{A 10} and p = 0.04 for MK₁₀) and lower 10th percentile of MD with variable against soft and firm (n = 5 vs 11; U test, p = 0.02). Higher standard deviation of MK_I in the rim was associated with lower grade (n = 22 vs 8; U test, p = 0.04) and in the MK_I maps we observed elevated rim-like structure that could be associated with grade. Higher median MK_A and lower median MK_I distinguished psammomatous type from other pooled meningioma types (n = 5 vs 25; U test; p = 0.03 for MK_{A 50} and p = 0.03 and p = 0.04 for MK_{I 50}).

Conclusion

Parameters from tensor-valued dMRI can facilitate prediction of consistency, grade and type.

SUBMITTER: Brabec J

PROVIDER: S-EPMC8688887 | biostudies-literature |

REPOSITORIES: biostudies-literature

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