Ontology highlight
ABSTRACT:
SUBMITTER: Moynihan E
PROVIDER: S-EPMC8688915 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Moynihan Eoin E Bassi Giada G Ruffini Andrea A Panseri Silvia S Montesi Monica M Velasco-Torrijos Trinidad T Montagner Diego D
Frontiers in chemistry 20211207
The selectivity <i>vs.</i> cancer cells has always been a major challenge for chemotherapeutic agents and in particular for cisplatin, one of the most important anticancer drugs for the treatment of several types of tumors. One strategy to overtake this challenge is to modify the coordination sphere of the metallic center with specific vectors whose receptors are overexpressed in the tumoral cell membrane, such as monosaccharides. In this paper, we report the synthesis of four novel glyco-modifi ...[more]