Overexpression of NEK2 is correlated with poor prognosis in human clear cell renal cell carcinoma.

ABSTRACT:

Objectives

Never in mitosis gene A-related kinase 2 (NEK2) has been implicated in tumorigenesis in various tissues, but its function in clear cell renal cell carcinoma (ccRCC) tumorigenesis is unclear. We evaluated the correlation between NEK2 expression and ccRCC.

Methods

Immunohistochemistry analysis of NEK2 protein was done on high-density multi-organ Human Cancer tissue microarray derived from the patient samples from clear cell renal cell carcinoma. We used multiple clinical cohorts to analyze the NEK2 immunohistochemical staining expression across human cancers. The cancer genome atlas (TCGA) data analysis of NEK2 was done through UALCAN web servers. Association of NEK2 and Kaplan-Meier survival analysis was done on both of our clinical database and available TCGA data

SUBMITTER: Wang C 

PROVIDER: S-EPMC8689635 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature