Isolation of SARS-CoV-2 B.1.1.28.2 (P2) variant and pathogenicity comparison with D614G variant in hamster model.

ABSTRACT:

Background

Considering the potential threat from emerging Severe Acute Respiratory Syndrome-Corona Virus-2 (SARS-CoV-2) variants and the rising COVID-19 cases, SARS-CoV-2 genomic surveillance is ongoing in India. We report herewith the isolation of the P.2 variant (B.1.1.28.2) from international travelers and further its pathogenicity evaluation and comparison with D614G variant (B.1) in hamster model.

Methods

Virus isolation was performed in Vero CCL81 cells and genomic characterization by next generation sequencing. The pathogenicity and host immune response of the isolate was assessed in Syrian hamster model and compared with B.1 variant.

Results

B.1.1.28.2 variant was isolated from nasal/throat swabs of international travelers returned to India from United Kingdom

SUBMITTER: Yadav P 

PROVIDER: S-EPMC8690136 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature