How robust are findings of pairwise and network meta-analysis in the presence of missing participant outcome data?

ABSTRACT:

Background

To investigate the prevalence of robust conclusions in systematic reviews addressing missing (participant) outcome data via a novel framework of sensitivity analyses and examine the agreement with the current sensitivity analysis standards.

Methods

We performed an empirical study on systematic reviews with two or more interventions. Pairwise meta-analyses (PMA) and network meta-analyses (NMA) were identified from empirical studies on the reporting and handling of missing outcome data in systematic reviews. PMAs with at least three studies and NMAs with at least three interventions on one primary outcome were considered eligible. We applied Bayesian methods to obtain the summary effect estimates whilst modelling missing outcome data under the missing-at-random assu

SUBMITTER: Spineli LM 

PROVIDER: S-EPMC8691029 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature