Dataset Information

No evidence of long-term disruption of glycometabolic control after SARS-CoV-2 infection.

ABSTRACT:

Purpose

To assess whether dysglycaemia diagnosed during SARS-CoV-2 pneumonia may become a potential public health problem after resolution of the infection. In an adult cohort with suspected COVID-19 pneumonia, we integrated glucose data upon hospital admission with fasting blood glucose (FBG) in the year prior to COVID-19 and during post-discharge follow-up.

Methods

From February 25th to May 15th 2020 660 adults with suspected COVID-19 pneumonia were admitted to the San Raffaele Hospital (Milan, Italy). Through structured interviews / medical record reviews we collected demographics, clinical features and laboratory tests upon admission and additional data during hospitalization or after discharge and in the previous year. Upon admission, we classified participants according to ADA criteria as having: a) pre-existing diabetes; b) newly diagnosed diabetes; c) hyperglycaemia not in the diabetes range; d) normoglycaemia. FBG prior to admission and during follow-up were classified as normal or impaired fasting glucose and fasting glucose in the diabetes range.

Results

In patients with confirmed COVID (n=589) the proportion with pre-existing or newly diagnosed diabetes, hyperglycaemia not in the diabetes range and normoglycaemia was 19.6%, 6.7%, 43.7% and 30.0%, respectively. Patients with dysglycaemia associated to COVID-19 had increased markers of inflammation and organs' injury and poorer clinical outcome compared to those with normoglycemia. After the infection resolved, the prevalence of dysglycaemia reverted to pre-admission frequency.

Conclusions

COVID-19 associated dysglycaemia is unlikely to become a lasting public health problem. Alarmist claims on the diabetes risk after COVID-19 pneumonia should be interpreted with caution.

SUBMITTER: Laurenzi A

PROVIDER: S-EPMC8691144 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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Publications

No Evidence of Long-Term Disruption of Glycometabolic Control After SARS-CoV-2 Infection.

Laurenzi Andrea A Caretto Amelia A Molinari Chiara C Mercalli Alessia A Melzi Raffaella R Nano Rita R Tresoldi Cristina C Rovere Querini Patrizia P Ciceri Fabio F Lampasona Vito V Bosi Emanuele E Scavini Marina M Piemonti Lorenzo L

The Journal of clinical endocrinology and metabolism 20220201 3

<h4>Purpose</h4>To assess whether dysglycemia diagnosed during severe acute respiratory syndrome coronavirus 2 pneumonia may become a potential public health problem after resolution of the infection. In an adult cohort with suspected coronavirus disease 2019 (COVID-19) pneumonia, we integrated glucose data upon hospital admission with fasting blood glucose (FBG) in the year prior to COVID-19 and during postdischarge follow-up.<h4>Methods</h4>From February 25 to May 15, 2020, 660 adults with sus ...[more]

PMID: 34718627

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