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Droplet-assisted electrospray phase separation using an integrated silicon microfluidic platform.

ABSTRACT: We report a silicon microfluidic platform that enables monolithic integration of transparent micron-scale microfluidic channels, an on-chip segmentation of analyte flows into picoliter-volume droplets, and a nano-electrospray ionization emitter that enables spatial and temporal separation of oil and aqueous phases during electro-spray for subsequent mass spectrometry analysis.

SUBMITTER: Zhang Y

PROVIDER: S-EPMC8691365 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Droplet-assisted electrospray phase separation using an integrated silicon microfluidic platform.

Zhang Yan Y Kim Sungho S Shi Weihua W Zhao Yaoyao Y Park Insu I Brenden Christopher C Iyer Hrishikesh H Jha Prasoon P Bashir Rashid R Sweedler Jonathan V JV Vlasov Yurii Y

Lab on a chip 20211221 1

We report a silicon microfluidic platform that enables monolithic integration of transparent micron-scale microfluidic channels, an on-chip segmentation of analyte flows into picoliter-volume droplets, and a nano-electrospray ionization emitter that enables spatial and temporal separation of oil and aqueous phases during electro-spray for subsequent mass spectrometry analysis. ...[more]

PMID: 34897344

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