Characterization of the L-form switch in the Gram-negative pathogen Streptobacillus moniliformis.

ABSTRACT: Almost all major classes of bacteria are surrounded by a peptidoglycan cell wall, which is a crucial target for antibiotics. It is now understood that many bacteria can tolerate loss of the cell wall provided that they are in an isotonic environment. Furthermore, in some cases the cells can continue to proliferate in a state known as the L-form. L-form proliferation occurs by an unusual blebbing or tubulation mechanism that is completely independent of the normally essential division machine or cell wall synthetic enzymes, and is resistant to cell wall-active antibiotics. However, the growth is limited by reactive oxygen species generated by the respiratory chain pathway. In this work, we examined the walled to L-form transition in a pathogenic Gram-negative bacterium, Streptobacillus moni

SUBMITTER: Roberts DM 

PROVIDER: S-EPMC8692008 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature