Ontology highlight
ABSTRACT:
SUBMITTER: McNeil MB
PROVIDER: S-EPMC8692989 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
McNeil Matthew B MB Ryburn Heath W HW Tirados Justin J Cheung Chen-Yi CY Cook Gregory M GM
iScience 20211204 1
<i>Mycobacterium tuberculosis</i> remains a leading cause of infectious disease morbidity and mortality for which new drug combination therapies are needed. Combinations of respiratory inhibitors can have synergistic or synthetic lethal interactions with sterilizing activity, suggesting that regimens with multiple bioenergetic inhibitors could shorten treatment times. However, realizing this potential requires an understanding of which combinations of respiratory complexes, when inhibited, have ...[more]