Preschool sleep and depression interact to predict gray matter volume trajectories across late childhood to adolescence.

ABSTRACT: There is a close relationship between sleep and depression, and certain maladaptive outcomes of sleep problems may only be apparent in individuals with heightened levels of depression. In a sample enriched for preschool depression, we examined how sleep and depression in early childhood interact to predict later trajectories of gray matter volume. Participants (N = 161) were recruited and assessed during preschool (ages 3-6 years) and were later assessed with five waves of structural brain imaging, spanning from late childhood to adolescence. Sleep and depression were assessed using a semi-structured parent interview when the children were preschool-aged, and total gray matter volume was calculated at each scan wave. Although sleep disturbances alone did not predict gray matter volume/traj

SUBMITTER: Hoyniak C 

PROVIDER: S-EPMC8693016 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature