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Engineering hybrid microgels as particulate emulsifiers for reversible Pickering emulsions.

ABSTRACT: Thermo-responsive microgels are unique stabilizers for stimuli-sensitive Pickering emulsions that can be switched between the state of emulsification and demulsification by changing the temperature. However, directly temperature-triggering the phase inversion of microgel-stabilized emulsions remains a great challenge. Here, a hybrid poly(N-isopropylacrylamide)-based microgel has now been successfully fabricated with tunable wettability from hydrophilicity to hydrophobicity in a controlled manner. Engineered microgels are synthesized from an inverse emulsion stabilized with hydrophobic silica nanoparticles, and the swelling-induced feature can make the resultant microgel behave like either hydrophilic or hydrophobic colloids. Remarkably, the phase inversion of such microgel-stabilized Pickering emulsions can be in situ regulated by temperature change. Moreover, the engineered microgels were capable of stabilizing water-in-oil Pickering emulsions and encapsulation of enzymes for interfacial bio-catalysis, as well as rapid cargo release triggered by phase inversion.

SUBMITTER: Jiang H

PROVIDER: S-EPMC8694365 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Engineering hybrid microgels as particulate emulsifiers for reversible Pickering emulsions.

Jiang Hang H Zhang Shengwei S Sun Guanqing G Li Yunxing Y Guan Xin X Yang Cheng C Ngai To T

Chemical science 20211029 1

Thermo-responsive microgels are unique stabilizers for stimuli-sensitive Pickering emulsions that can be switched between the state of emulsification and demulsification by changing the temperature. However, directly temperature-triggering the phase inversion of microgel-stabilized emulsions remains a great challenge. Here, a hybrid poly(<i>N</i>-isopropylacrylamide)-based microgel has now been successfully fabricated with tunable wettability from hydrophilicity to hydrophobicity in a controlled ...[more]

PMID: 35059148

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Project description:Periodontitis (PD) as a chronic inflammatory disease instigated by periodontal pathogenic bacteria and mediated by the host immune response, resulting in the destruction of supporting periodontal tissue and tooth loss in adults. Constructing an injectable delivery system that allows for sustained drug release within periodontal pockets to continuously eliminate pathogenic bacteria, reduce periodontal inflammation, and promote periodontal tissue regeneration is an effective strategy for periodontitis treatment. Here, we explore the therapeutic potential and underlying mechanisms of curcumin-loaded Pickering emulsion (PE-CUR) in periodontitis treatment. The Pickering emulsion formulation offers an effective delivery system, enhancing curcumin's bioavailability and therapeutic efficacy. In vitro studies, we demonstrate that the PE-CUR exhibit excellent biocompatibility and anti-inflammatory property by elimination of reactive oxygen species (ROS). In addition, PE-CUR significantly eliminate key periodontal pathogens, including Porphyromonas gingivalis (P. gingivalis) and Staphylococcus aureus (S. aureus). In a rat model of periodontitis, PE-CUR significantly attenuates periodontal tissue inflammation and alveolar bone loss, indicating a protective effect against periodontal tissue destruction. Mechanistically, PE-CUR promotes the expression of anti-inflammatory factors and inhibits the release of pro-inflammatory factors by regulating macrophage polarization from M1 to M2 and modulating the MAPK and PI3K-AKT signaling pathway. Furthermore, PE-CUR decreases the formation of osteoclasts as well as stimulates the activation and differentiation of osteoblasts successively, thereby ameliorating the periodontal inflammation and promoting the alveolar bone regeneration. Overall, our findings elucidate the therapeutic mechanisms of PE-CUR in periodontitis, suggesting its potential as a promising treatment strategy warranting further clinical investigation.

Dataset Information

Engineering hybrid microgels as particulate emulsifiers for reversible Pickering emulsions.

Publications

Engineering hybrid microgels as particulate emulsifiers for reversible Pickering emulsions.

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