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Vitamin D: Dosing, levels, form, and route of administration: Does one approach fit all?

ABSTRACT: The 4^th International Conference on Controversies in Vitamin D was held as a virtual meeting in September, 2020, gathering together leading international scientific and medical experts in vitamin D. Since vitamin D has a crucial role in skeletal and extra-skeletal systems, the aim of the Conference was to discuss improved management of vitamin D dosing, therapeutic levels and form or route of administration in the general population and in different clinical conditions. A tailored approach, based on the specific mechanisms underlying vitamin D deficiency in different diseases that were discussed, was recommended. Specifically, in comparison to healthy populations, higher levels of vitamin D and greater amounts of vitamin D were deemed necessary in osteoporosis, diabetes mellitus, obesity (particularly after bariatric surgery), and in those treated with glucocorticoids. Emerging and still open issues were related to target vitamin D levels and the role of vitamin D supplementation in COVID-19 since low vitamin D may predispose to SARS-CoV-2 infection and to worse COVID-19 outcomes. Finally, whereas oral daily cholecalciferol appears to be the preferred choice for vitamin D supplementation in the general population, and in most clinical conditions, active vitamin D analogs may be indicated in patients with hypoparathyroidism and severe kidney and liver insufficiency. Parenteral vitamin D administration could be helpful in malabsorption syndromes or in states of vitamin D resistance.Specific guidelines for desired levels of vitamin D should be tailored to the different conditions affecting vitamin D metabolism with the goal to define disease-specific normative values.

SUBMITTER: Bilezikian JP

PROVIDER: S-EPMC8696970 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Vitamin D: Dosing, levels, form, and route of administration: Does one approach fit all?

Bilezikian John P JP Formenti Anna Maria AM Adler Robert A RA Binkley Neil N Bouillon Roger R Lazaretti-Castro Marise M Marcocci Claudio C Napoli Nicola N Rizzoli Rene R Giustina Andrea A

Reviews in endocrine & metabolic disorders 20211223 4

The 4<sup>th</sup> International Conference on Controversies in Vitamin D was held as a virtual meeting in September, 2020, gathering together leading international scientific and medical experts in vitamin D. Since vitamin D has a crucial role in skeletal and extra-skeletal systems, the aim of the Conference was to discuss improved management of vitamin D dosing, therapeutic levels and form or route of administration in the general population and in different clinical conditions. A tailored app ...[more]

PMID: 34940947

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Vitamin D: Dosing, levels, form, and route of administration: Does one approach fit all?

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Vitamin D: Dosing, levels, form, and route of administration: Does one approach fit all?

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